Endocrine Abstracts

Factors affecting the development of nephrolithiasis (NL) in primary hyperparathyroidism (PHPT) actively studied. CASR polymorphisms may be linked with the development of NL in PHPT. Supposed to the role of VDR in the development of nephrolithiasis in patients without PHPT.Objective: To assess the relationship of polymorphisms CASR and VDR with the development of the NL at PGPT.Methods: The study included 187 patients with PTPT (54...

Clinical manifestations and severity vary considerably primary hyperparathyroidism (PHPT) patients. Several studies indicate that the variation of clinical manifestations PHPT may be associated with genetic factors, in particular the VDR gene polymorphisms and CASR. The purpose of this study was to evaluate the effect of VDR gene polymorphisms and CASR on indicators calcium and phosphorus metabolism, levels of 25(OH)D, PTH, and condition of bone density in patients with PHPT.<...

Much attention is attracted increased risk of fractures in patients with urolithiasis. Study the possible relationship of pathophysiological mechanisms of osteoporosis/osteopenia and nephrolithiasis.Objective: To assess the state of bone metabolism, vitamin D level in patients with urolithiasis compared with healthy individuals.Methods: Were examined 58 patients with nephrolithiasis (36 women, and 22 men) and 20 healthy individuals...